Besnoitia besnoiti protein disulfide isomerase (BbPDI): Molecular characterization, expression and in silico modelling
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چکیده
منابع مشابه
Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterization, expression and in silico modelling.
Besnoitia besnoiti is an apicomplexan parasite responsible for bovine besnoitiosis, a disease with a high prevalence in tropical and subtropical regions and re-emerging in Europe. Despite the great economical losses associated with besnoitiosis, this disease has been underestimated and poorly studied, and neither an effective therapy nor an efficacious vaccine is available. Protein disulfide is...
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Protein disulfide isomerases (PDI) are involved in catalyzing protein disulfide bonding and isomerization in the endoplasmic reticulum and functions as a chaperone to inhibit the aggregation of misfolded proteins. Brachypodium distachyon is a widely used model plant for temperate grass species such as wheat and barley. In this work, we report the first molecular characterization, phylogenies, a...
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Protein disulfide isomerase (PDI) and PDI-like proteins are members of the thioredoxin superfamily. They contain thioredoxin-like domains and catalyze the physiological oxidation, reduction and isomerization of protein disulfide bonds, which are involved in cell function and development in prokaryotes and eukaryotes. In this study, EtPDIL, a novel PDI-like gene of Eimeria tenella, was cloned us...
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Besnoitia besnoiti is an economically important tissue cyst-forming apicomplexan of cattle in Africa and Israel. Tissue cysts and bradyzoites of B. besnoiti from the skin of a naturally infected bull were studied by transmission electron microscopy. Tissue cysts enclosed host cell and bradyzoites. Bradyzoites were 6-7.5 x 1.9-2.3 microm in size and contained organelles found in coccidian merozo...
متن کاملChemotherapy of experimental Besnoitia besnoiti infection in rabbits.
Rabbits were infected with a bovine strain of Besnoitia besnoiti parasites derived from VERO cell cultures. Oxytetracycline, given at 30 mg/kg i.m. simultaneously with infection, prevented the development of orchitis. The controls received no treatment. All infected animals showed a transient febrile reaction. It is concluded that oxytetracycline has some therapeutic potential against Besnoitia...
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ژورنال
عنوان ژورنال: Experimental Parasitology
سال: 2011
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2011.06.012